Antibiotic Spectrum

33 agents · click a drug for dosing & details · filters dim non-matching cards

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β-Lactams Glycopeptides Lipopeptides Oxazolidinones Macrolides Tetracyclines Fluoroquinolones Aminoglycosides Sulfonamides Lincosamides Nitroimidazoles Nitrofurans Phosphonic acids Other

β-Lactams

Penicillins

Cephalosporins — 1st generation

Cephalosporins — 3rd generation

Cephalosporins — 4th generation

Cephalosporins — 5th generation

Carbapenems

Monobactams

Glycopeptides

Lipopeptides

Oxazolidinones

Macrolides

Tetracyclines

Fluoroquinolones

Aminoglycosides

Sulfonamides

Lincosamides

Nitroimidazoles

Nitrofurans

Phosphonic acids

Other

Linezolid(Zyvox)

Oxazolidinone

Routes: IV, PO

Dosing

Most infections
600 mg · q12h · IV
Duration: varies
Most infections (PO)
600 mg · q12h · PO
Duration: varies
100% PO bioavailability.

Adverse effects

Thrombocytopenia (especially >2 weeks)
Peripheral / optic neuropathy (prolonged use)
Lactic acidosis
Serotonin syndrome with serotonergic agents

Drug interactions

MAO-inhibitor activity — avoid with SSRIs, SNRIs, MAOIs, tramadol, meperidine, linezolid + serotonergic agents

Allergy class

Oxazolidinone

Cross-reactivity: tedizolid

Monitoring

CBC weekly if >2 weeks
Visual changes if >28 days
Lactate if symptoms

PK / Distribution

Distribution: Excellent — CSF, lung, bone, skin, abscess.

Clearance: Hepatic / non-renal — no renal adjustment needed.

Pregnancy / Lactation

Limited data — avoid unless no alternative.

Cost

Expensive.

Pearls

Bacteriostatic — generally avoid as monotherapy for endocarditis. 100% oral bioavailability is the killer feature for IV-to-PO switch.

Citations

IDSA MRSA guidelines (2011)

Full monograph (UCSF/IDMP)

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