Antibiotic Spectrum

33 agents · click a drug for dosing & details · filters dim non-matching cards

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β-Lactams Glycopeptides Lipopeptides Oxazolidinones Macrolides Tetracyclines Fluoroquinolones Aminoglycosides Sulfonamides Lincosamides Nitroimidazoles Nitrofurans Phosphonic acids Other

β-Lactams

Penicillins

Cephalosporins — 1st generation

Cephalosporins — 3rd generation

Cephalosporins — 4th generation

Cephalosporins — 5th generation

Carbapenems

Monobactams

Glycopeptides

Lipopeptides

Oxazolidinones

Macrolides

Tetracyclines

Fluoroquinolones

Aminoglycosides

Sulfonamides

Lincosamides

Nitroimidazoles

Nitrofurans

Phosphonic acids

Other

Clindamycin(Cleocin)

Lincosamide

Routes: PO, IV

Dosing

SSTI / aspiration
600 mg · q8h · IV
SSTI (PO)
300–450 mg · q6–8h · PO
PCP — moderate–severe (combo with primaquine)
600 mg IV q6h or 450 mg PO q6h · q6h · IV
Duration: 21 days
Pair with primaquine 30 mg base PO daily; check G6PD before primaquine.
Toxoplasmosis (combo with pyrimethamine + leucovorin)
600 mg · q6h · IV/PO
Duration: ≥6 weeks acute, then chronic suppression in HIV

Adverse effects

C. difficile (highest risk antibiotic)
Rash
GI upset

Drug interactions

—

Allergy class

Lincosamide

Monitoring

—

PK / Distribution

Distribution: Excellent — bone, lung, abscess, soft tissue. NO CSF.

Clearance: Hepatic.

Pregnancy / Lactation

Safe.

Cost

Cheap.

Pearls

Above-diaphragm anaerobes (oral, lung). Suppresses toxin production in toxin-mediated infections (nec fasc, TSS). High C. diff risk. Inducible MRSA resistance — request D-test. Combo with primaquine is a TMP-SMX-sparing option for moderate–severe PCP, especially in sulfa allergy. Combo with pyrimethamine for cerebral toxoplasmosis when sulfa-intolerant.

Citations

IDSA SSTI guidelines (2014)
ATS/IDSA HIV-Related Pneumonia (2009)

Full monograph (UCSF/IDMP)

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